peak
Back to all substances
59

Alpha-GPC

Also known as: L-Alpha glycerylphosphorylcholine, Choline Alfoscerate

Choline Source

Nootropic
B

Tier B

Multiple RCTs (n>100)

T2Partial ProfileAcute

Highly bioavailable choline source that crosses the blood-brain barrier effectively. Popular as a nootropic and in athletic supplements.

Mechanism of Action

Precursor to acetylcholine. Increases phosphatidylcholine synthesis. May stimulate growth hormone release.

Contraindications

  • Potential increased stroke risk with long-term high doses (research ongoing)

Performance Profile

Focus
+2
Memory
+4
Processing Speed
+1
Mental Clarity
+2
Creativity
+1
Learning
+3

Dosage

300mg

min

600mg

1200mg

max

Timing

Best time

Morning

30 min

onset

6 hr

duration

Half-life
4 hr

Safety & Legal

9/10

Well-tolerated

Legal Status

OTC

Mild
Moderate
Severe
Headache
0.1-1%mild
Dizziness
<0.1%mild
Heartburn
0.1-1%mild