Ashwagandha (KSM-66)

Also known as: Withania somnifera, Indian Ginseng

Ayurvedic

Adaptogen

Tier A

Meta-analysis of RCTs (n>500)

T1Full ProfileAdaptive

Premier adaptogen for stress reduction. Significantly lowers cortisol levels and supports testosterone. Requires 4-8 weeks for full effects.

Mechanism of Action

Contains withanolides that modulate HPA axis function. Reduces cortisol via GABAergic activity. May enhance GABA receptor sensitivity.

Contraindications

Thyroid disorders (may increase thyroid hormones)
Autoimmune conditions (may stimulate immune system)
Pregnancy and breastfeeding

Performance Profile

Mood

Stress Resistance

Anxiety Reduction

Emotional Stability

Dosage

300mg

min

600mg

1200mg

max

Timing

Best time

Evening

2 wk

onset

1 mo

duration

Half-life

6 hr

Safety & Legal

9/10

Well-tolerated

Legal Status

OTC

Mild

Moderate

Severe

Gastrointestinal upset

0.1-1%mild

Drowsiness

0.1-1%mild

Thyroid hormone increase

<0.1%moderate