Baclofen

Also known as: Lioresal, Gablofen

GABA-B Agonist

Prescription

Tier A

Meta-analysis of RCTs (n>500)

T1Full ProfileAcute

Muscle relaxant and GABA-B agonist. Used off-label for anxiety, alcohol withdrawal, and spasticity. Requires careful dose titration.

Mechanism of Action

Selective GABA-B receptor agonist. Reduces excitatory neurotransmission. Muscle relaxation via spinal cord effects.

Contraindications

Do not discontinue abruptly (taper required)
Kidney impairment (dose adjustment needed)
History of seizures

Performance Profile

Sleep Quality

Sleep Onset

Deep Sleep

Recovery Speed

Dosage

5mg

min

10mg

40mg

max

Timing

Best time

Evening

1 hr

onset

6 hr

duration

Half-life

4 hr

Safety & Legal

5/10

Use caution

Legal Status

Prescription

Mild

Moderate

Severe

Drowsiness

>10%moderate

Dizziness

1-10%mild

Weakness

1-10%mild

Withdrawal seizures

<0.1%severe