59

Caffeine

Stimulant

Most widely used psychoactive substance. Blocks adenosine receptors to promote wakefulness.

Onset15m
Duration4h
Half-life5h
Safety9/10

Effects Profile

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Dosage & Timing

Dosage Range

50

mg

100mg

400

mg

Best time

Morning

Legal (US/EU)

OTC

Tips

  • Combine with L-theanine (2:1 ratio) for smooth focus
  • Avoid after 2pm to protect sleep quality
  • Tolerance builds quickly - consider cycling

Safety

Contraindications

  • Severe anxiety disorders
  • Uncontrolled hypertension
  • Cardiac arrhythmias

Side Effects

mild
moderate
severe
Jitteriness
1-10%
Increased heart rate
1-10%
Insomnia
1-10%

Mechanism

Competitive antagonist at adenosine A1 and A2A receptors. Increases dopamine signaling indirectly.