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Methylphenidate
Also known as: Ritalin, Concerta, Medikinet
Stimulant
PrescriptionT1Full ProfileAcute
A
Tier A
Meta-analysis of RCTs (n>500)
Dopamine-norepinephrine reuptake inhibitor. First-line treatment for ADHD. Significant cognitive enhancement but notable side effects.
Mechanism of Action
Blocks dopamine and norepinephrine transporters. Increases catecholamine concentrations in prefrontal cortex and striatum.
Contraindications
- Cardiovascular disease
- Hyperthyroidism
- Glaucoma
- History of drug abuse
- MAOI use within 14 days
Performance Profile
Physical Energy
+3
Mental Stamina
+4
Alertness
+5
Motivation
+4
Dosage
5mg
min
20mg
60mg
max
Timing
Best time
Morning
30 min
onset
4 hr
duration
Half-life
3 hrSafety & Legal
6/10
Generally safe
Legal Status
Prescription
Mild
Moderate
Severe
Appetite suppression
>10%moderate
Insomnia
>10%moderate
Increased heart rate
1-10%mild
Anxiety
1-10%moderate
Cardiovascular events
<0.1%severe