55

Methylphenidate

Stimulant

Prescription / Controlled

Requires valid prescription. Educational purposes only.

US: controlledEU: prescription

First-line ADHD medication. Enhances dopamine and norepinephrine in prefrontal cortex.

Onset30m
Duration4h
Half-life3h
Safety6/10

Effects Profile

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Dosage & Timing

Dosage Range

5

mg

20mg

60

mg

Best time

Morning

USControlled
EUPrescription

Tips

  • Start low, titrate slowly
  • Take early to avoid insomnia
  • Monitor heart rate and blood pressure
  • Drug holidays may preserve efficacy

Safety

Contraindications

  • Glaucoma
  • Severe anxiety
  • MAOIs within 14 days
  • Cardiovascular disease
  • History of substance abuse

Side Effects

mild
moderate
severe
Decreased appetite
>10%
Insomnia
>10%
Increased heart rate
1-10%
Anxiety
1-10%

Mechanism

Blocks dopamine and norepinephrine transporters (DAT, NET), increasing synaptic concentrations.