Phenibut

Also known as: β-Phenyl-γ-aminobutyric acid, Noofen

GABA Analogue

Prescription

Tier C

Single RCT or lower-quality studies

T2Partial ProfileAcute

GABA analogue with potent anxiolytic and nootropic effects. Russian development. HIGH addiction potential - strict usage limits required.

Mechanism of Action

GABA-B agonist and α2δ calcium channel blocker (similar to gabapentin). Crosses blood-brain barrier due to phenyl ring.

Contraindications

HIGH addiction potential - use MAX 1-2x per week
Never use daily
Severe withdrawal possible after regular use
Do not combine with alcohol or other GABAergics

Performance Profile

Mood

Stress Resistance

Anxiety Reduction

Emotional Stability

Dosage

250mg

min

500mg

1500mg

max

Timing

Best time

Evening

2 hr

onset

8 hr

duration

Half-life

5 hr

Safety & Legal

4/10

Use caution

Legal Status

Unregulated

Mild

Moderate

Severe

Drowsiness

1-10%moderate

Dizziness

1-10%mild

Tolerance (rapid)

>10%moderate

Withdrawal (severe)

1-10%severe