Pregabalin

Also known as: Lyrica

Gabapentinoid

Prescription

Tier A

Meta-analysis of RCTs (n>500)

T1Full ProfileAcute

Calcium channel modulator for anxiety, neuropathic pain, and epilepsy. Has euphoric effects at higher doses. Controlled substance in many countries.

Mechanism of Action

Binds to α2δ subunit of voltage-gated calcium channels. Reduces calcium influx and neurotransmitter release. Not a GABA analog despite the name.

Contraindications

History of substance abuse
Heart failure (may worsen edema)
Avoid abrupt discontinuation

Performance Profile

Mood

Stress Resistance

Anxiety Reduction

Emotional Stability

Dosage

75mg

min

150mg

600mg

max

Timing

Best time

Evening

1 hr

onset

8 hr

duration

Half-life

6 hr

Safety & Legal

5/10

Use caution

Legal Status

Prescription

Mild

Moderate

Severe

Dizziness

>10%moderate

Somnolence

>10%moderate

Weight gain

1-10%mild

Peripheral edema

1-10%mild

Dependence

0.1-1%severe